Bengal Physician Journal

Register      Login

VOLUME 10 , ISSUE 3 ( September-December, 2023 ) > List of Articles


A Case of Tuberous Sclerosis Presenting with Gelastic Seizures

Naga Srinivas PS, Malcolm Jeyaraj, Sakthi Velayudham, Sowmini Perumal, Kannan Vellaichamy, Viveka Saravanan Raju, Mugundhan Krishnan

Keywords : Case report, Cortical tubers, Gelastic seizure, Tuberous sclerosis complex

Citation Information : Srinivas PS N, Jeyaraj M, Velayudham S, Perumal S, Vellaichamy K, Raju VS, Krishnan M. A Case of Tuberous Sclerosis Presenting with Gelastic Seizures. Bengal Physician Journal 2023; 10 (3):99-101.

DOI: 10.5005/jp-journals-10070-8011

License: CC BY-NC 4.0

Published Online: 21-12-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Gelastic seizures (GS), an uncommon epileptic seizure type, have been described as the hallmark of seizures arising from the hypothalamus, with hypothalamic hamartoma (HH) being the frequent underlying pathology. These are mostly seen in children as intractable seizures with sudden outbursts of unprovoked stereotyped laughter as the main ictal manifestation, commonly in association with precocious puberty, behavioral disturbances, and cognitive impairment. Gelastic seizures are also seen with complex partial seizures of the frontal or temporal lobe as well as the cingulate gyrus with or without radiologically evident structural lesions. Herein, we present a child with tuberous sclerosis complex (TSC) who presented with GS not associated with HH.

  1. Kovac S, Diehl B, Wehner T, et al. Gelastic seizures: Incidence, clinical and EEG features in adult patients undergoing video-EEG telemetry. Epilepsia 2015;56(1):e1–e5. DOI: 10.1111/epi.12868.
  2. Khadilkar S, Menezes K, Lele V, et al. Gelastic epilepsy: A case report with SPECT studies. J Assoc Physicians India 2001;49:581–583. PMID: 11361281.
  3. Cook T, Joshi C. Gelastic seizures in tuberous sclerosis complex: Case report and literature review. J Child Neurol 2011;26(1):83–86. DOI: 10.1177/0883073810370478.
  4. Scholly J, Valenti M-P, Staack AM, et al. Hypothalamic hamartoma: Is the epileptogenic zone always hypothalamic? Arguments for independent (third stage) secondary epileptogenesis. Epilepsia 2013;54(Suppl 9):123–128. DOI: 10.1111/epi.12456.
  5. Gascon GG, Lombroso CT. Epileptic (gelastic) laughter. Epilepsia 1971;12(1):63–76. DOI: 10.1111/j.1528-1157.1971.tb03916.x.
  6. Iapadre G, Zagaroli L, Cimini N, et al. Gelastic seizures not associated with hypothalamic hamartoma: A long-term follow-up study. Epilepsy Behav 2020;103(Pt A):106578. DOI: 10.1016/j.yebeh.2019.106578.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.