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VOLUME 11 , ISSUE 1 ( January-April, 2024 ) > List of Articles


Antimicrobial Resistance in Human Health: A Comprehensive Review of One Health Approach

Shambo S Samajdar, Nandini Chatterjee, Sougata Sarkar, Jyotirmoy Pal, Tapan K Mondal, Santanu Tripathi, Shashank R Joshi

Keywords : Antimicrobial resistance, Eco-epidemiology, Interconnected, One health, Threat

Citation Information : Samajdar SS, Chatterjee N, Sarkar S, Pal J, Mondal TK, Tripathi S, Joshi SR. Antimicrobial Resistance in Human Health: A Comprehensive Review of One Health Approach. Bengal Physician Journal 2024; 11 (1):18-23.

DOI: 10.5005/jp-journals-10070-8039

License: CC BY-NC 4.0

Published Online: 18-04-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Antimicrobial resistance (AMR) poses a complex and interconnected global challenge affecting human health, animal health, and the environment. This comprehensive review explores the multifaceted dimensions of AMR and highlights the pivotal role of the One Health approach in addressing this pressing issue. The discussion emphasizes evidence-based strategies, integrated surveillance, and effective communication to inform decision-making and policy formulation. Furthermore, the economic implications of AMR and the need for a paradigm shift toward holistic One Health models are examined. The World Health Organization's (WHO) Global Action Plan and stakeholder engagement across various sectors are emphasized as critical components of AMR control. The review also delves into the importance of research and surveillance in understanding AMR drivers and developing alternatives to antibiotics. Promising approaches, such as microbiota modulation, gene editing, vaccines, antivirulence inhibitors, and bacteriophages, are explored as innovative means to combat AMR. Overall, this review underscores the urgency of a coordinated, multidisciplinary One Health approach in mitigating the global threat of AMR.

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  1. Robinson TP, Bu DP, Carrique-Mas J, et al. Antibiotic resistance is the quintessential one health issue. Trans R Soc Trop Med Hyg 2016;110(7):377–380. DOI: 10.1093/trstmh/trw048.
  2. Hernando-Amado S, Coque TM, Baquero F, et al. Defining and combating antibiotic resistance from one health and global health perspectives. Nat Microbiol 2019;4(9):1432–1442. DOI: 10.1038/s41564-019-0503-9.
  3. Marti E, Variatza E, Balcazar JL. The role of aquatic ecosystems as reservoirs of antibiotic resistance. Trends Microbiol 2014;22(1):36–41. DOI: 10.1016/j.tim.2013.11.001.
  4. Burow E, Käsbohrer A. Risk factors for antimicrobial resistance in Escherichia coli in pigs receiving oral antimicrobial treatment: A systematic review. Microb Drug Resist 2017;23(2),194–205. DOI: 10.1089/mdr.2015.0318.
  5. Huijbers PM, Blaak H, de Jong MC, et al. Role of the environment in the transmission of antimicrobial resistance to humans: A review. Environ Sci Technol 2015;49(20):11993–12004. DOI: 10.1021/acs.est.5b02566.
  6. Chang Q, Wang W, Regev-Yochay G, et al. Antibiotics in agriculture and the risk to human health: How worried should we be? Evol Appl 2015;8(3):240–247. DOI: 10.1111/eva.12185.
  7. O'Neill J. Antimicrobials in agriculture and the environment: Reducing unnecessary use and waste. Rev Antimicrob Resist Wellcome Trust (London, England) 2015;1–44. Available from:
  8. Holmes AH, Moore LS, Sundsfjord A, et al. Understanding the mechanisms and drivers of antimicrobial resistance. Lancet (London England) 2016;387(10014):176–187. DOI: 10.1016/S0140-6736(15)00473-0.
  9. Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance: A global multifaceted phenomenon. Pathog Global Health 2015;109(7): 309–318. DOI: 10.1179/2047773215Y.0000000030.
  10. Malik AA, Hussain H, Creswell J, et al. The impact of funding on childhood TB case detection in Pakistan. Trop Med Infect Dis 2019;4(4):146. DOI: 10.3390/tropicalmed4040146.
  11. Organization WH (2004). Joint FAO/OIE/WHO Expert Workshop on Non-Human Antimicrobial Usage and Antimicrobial Resistance: Scientific Assessment. December 1–5, 2003. (Geneva: World Health Organization). Available from:
  12. Organization WH (2014a). Antimicrobial Resistance Global Report on Surveillance. 2014 Summary. (World Health Organization). Available from:
  13. Organization WH (2014b). Antimicrobial Resistance: Global Report on Surveillance. (Geneva, Switzerland: World Health Organization). Available from:
  14. Organization WH (2017). Integrated Surveillance of Antimicrobial Resistance in Foodborne Bacteria: Application of a One Health Approach: Guidance From the WHO Advisory Group on Integrated Surveillance of Antimicrobial Resistance (AGISAR). Available from:
  15. Theilen U, Wilson L, Wilson G, et al. Management of invasive meningococcal disease in children and young people: Summary of sign guidelines. BMJ (Clinical research ed.) 2008;336(7657):1367–1370. DOI: 10.1136/bmj.a129.
  16. McEwen SA, Collignon PJ. Antimicrobial resistance: A one health perspective: Schwarz S, Cavaco LM, Shen J, Antimicrobial resistance in bacteria from livestock and companion animals. 2018. pp. 521–547. DOI:
  17. Landers TF, Cohen B, Wittum TE, et al. A review of antibiotic use in food animals: Perspective, policy, and potential. Public Health Rep 2012;127(1):4–22. DOI: 10.1177/003335491212700103.
  18. McEwen SA, Fedorka-Cray PJ. Antimicrobial use and resistance in animals. Clin Infect Dis 2002;34(Suppl 3):S93–S106. DOI: 10.1086/340246.
  19. Samajdar SS, Bhattacharya S. Rich with rupees or rich in good gut microbiota: What is more important for our metabolic health? Explor Anim Med Res 2019;9(2):105–107.
  20. National Research Council Committee on Drug Use in Food a (1999). The Use of Drugs in Food Animals: Benefits and Risks. Washington, DC: National Academies Press (US). ©1999 by the National Academy of Sciences. All rights reserved.
  21. Ruppé, Chappuis F. What and how should we tell travellers about antimicrobial resistance? J Travel Med 2017;24(2). DOI: 10.1093/jtm/taw089.
  22. Kirchhelle C. Pharming animals: A global history of antibiotics in food production (1935–2017). Palgrave Commun 2018;4(1):96. DOI: 10.1057/s41599-018-0152-2.
  23. Auta A, Hadi MA, Oga E, et al. Global access to antibiotics without prescription in community pharmacies: A systematic review and meta-analysis. J Infect 2019;78(1):8–18. DOI: 10.1016/j.jinf.2018. 07.001.
  24. Van Boeckel TP, Glennon EE, Chen D, et al. Reducing antimicrobial use in food animals. Science (New York N.Y.) 2017;357(6358):1350–1352. DOI: 10.1126/science.aao1495.
  25. Done HY, Venkatesan AK, Halden RU. Does the recent growth of aquaculture create antibiotic resistance threats different from those associated with land animal production in agriculture? AAPS J 2015;17(3):513–524. DOI: 10.1208/s12248-015-9722-z.
  26. He Y, Yuan Q, Mathieu J, et al. Antibiotic resistance genes from livestock waste: Occurrence, dissemination, and treatment. NPJ Clean Water 2020;3(1):4. DOI: 10.1038/s41545-020-0051-0.
  27. Stalder T, Press MO, Sullivan S, et al. Linking the resistome and plasmidome to the microbiome. ISME J 2019;13(10):2437–2446. DOI: 10.1038/s41396-019-0446-4.
  28. Griffiths E, Dooley D, Graham M, et al. Context is everything: Harmonization of critical food microbiology descriptors and metadata for improved food safety and surveillance. Front Microbiol 2017;8:1068. DOI: 10.3389/fmicb.2017.01068.
  29. Velazquez-Meza ME, Galarde-López M, Carrillo-Quiróz B, et al. Antimicrobial resistance: One health approach. Vet World 2022;15(3):743–749. DOI: 10.14202/vetworld.2022.743-749.
  30. Collignon PJ, McEwen SA. One health – Its importance in helping to better control antimicrobial resistance. Trop Med Infect Dis 2019 29;4(1):22. DOI: 10.3390/tropicalmed4010022.
  31. Raina SK, Kumar R. “Vasudaiva kutumbakam-one earth, one family, one future”:- India's mantra for a healthy and prosperous earth as the G20 leader. J Family Med Prim Care 2023;12(2):191–193. DOI: 10.4103/jfmpc.jfmpc_254_23.
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