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VOLUME 7 , ISSUE 1 ( January-April, 2020 ) > List of Articles

REVIEW ARTICLE

Gut Microbiota and Extraintestinal Disorders: Are They Interrelated?

Atanu Chandra, Aritra K Ray, Uddalak Chakraborty, Arkapravo Hati

Keywords : Dysbiosis, Extraintestinal diseases, Gut microbiota, Irritable bowel syndrome

Citation Information : Chandra A, Ray AK, Chakraborty U, Hati A. Gut Microbiota and Extraintestinal Disorders: Are They Interrelated?. Bengal Physician Journal 2020; 7 (1):8-11.

DOI: 10.5005/jp-journals-10070-7012

License: CC BY-NC 4.0

Published Online: 18-02-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Normally in health, the commensal gut microbiota lives in a perfectly symbiotic relationship with the host. Initial bacterial colonization occurs through the maternal vaginal/fecal flora and oral feeding. When this symbiotic relationship is lost due to several factors, the condition is known as “dysbiosis.” Dysbiosis is associated with the pathogenesis of intestinal disorders, such as inflammatory bowel disease, irritable bowel syndrome (IBS), and coeliac disease, but recent studies have shown that it has also been implicated in extraintestinal disorders, such as allergy, asthma, cardiovascular disease, obesity, autoimmune diseases, inflammatory diseases, and some mental disorders and cancers. The proposed mechanism for the development of such disorders is disruption of the pivotal mutual relationship between the gut microbiome, the metabolic products produced by them, and the host immune response. In this review article, we would like to highlight the role of gut microbiota in the development of extraintestinal diseases.


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