Drug-induced encephalopathy is a well-known side effect of many drugs. Isoniazid (INH), a first-line drug used in the treatment of tuberculosis, can cause encephalopathy in chronic kidney disease (CKD) patients though other isoniazid-related neurotoxicities are more commonly encountered in general population. We report isoniazid-induced encephalopathy in a female patient with CKD. She has been given rifampicin, INH, pyrazinamide, and ethambutol with pyridoxine and prednisolone for the treatment of Pott's disease of cervical spine. The patient developed recurrent episodes of altered consciousness following the treatment. After exclusion of other causes, isoniazid-induced encephalopathy was suspected, which was further proved by symptomatic improvement after stopping isoniazid.