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VOLUME 7 , ISSUE 1 ( January-April, 2020 ) > List of Articles


Isoniazid-induced Encephalopathy in a Chronic Kidney Disease Patient: A Case Report

Md. Adnanul Alam, Muhammad Jamal Uddin, Abed H Khan, Shohael M Arafat

Keywords : Isoniazid-induced encephalopathy, Tuberculosis,Chronic kidney disease

Citation Information : Alam MA, Uddin MJ, Khan AH, Arafat SM. Isoniazid-induced Encephalopathy in a Chronic Kidney Disease Patient: A Case Report. Bengal Physician Journal 2020; 7 (1):14-16.

DOI: 10.5005/jp-journals-10070-7013

License: CC BY-NC 4.0

Published Online: 18-02-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Drug-induced encephalopathy is a well-known side effect of many drugs. Isoniazid (INH), a first-line drug used in the treatment of tuberculosis, can cause encephalopathy in chronic kidney disease (CKD) patients though other isoniazid-related neurotoxicities are more commonly encountered in general population. We report isoniazid-induced encephalopathy in a female patient with CKD. She has been given rifampicin, INH, pyrazinamide, and ethambutol with pyridoxine and prednisolone for the treatment of Pott\'s disease of cervical spine. The patient developed recurrent episodes of altered consciousness following the treatment. After exclusion of other causes, isoniazid-induced encephalopathy was suspected, which was further proved by symptomatic improvement after stopping isoniazid.

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