Coronavirus disease-2019 (COVID-19) has emerged as a pandemic affecting millions of people worldwide. It is characterized by multisystem involvement. The endocrine organs are also expected to be affected in COVID-19 as the interplay between the virus, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), and the endocrine system occurs at multiple organ levels with a swarm of clinical manifestations. In addition to other organ systems, COVID-19 also affects persons with known endocrine disorders, thereby making them susceptible to an increased risk of disease severity, worse prognosis, and increased mortality. However, the virus being a novel one, its possible effect on the endocrine system is not yet entirely understood with limited clinical data to date and remains an emerging area of further research. In this review, the variety of endocrine manifestations that have been reported in both SARS-CoV-1 and SARS-CoV-2 to date have been highlighted. Besides, the possible mechanisms by which SARS-CoV-2 may affect various endocrine organs have been explored.
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