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VOLUME 7 , ISSUE 3 ( September-December, 2020 ) > List of Articles

REVIEW ARTICLE

Cytokine Storm

Satyabrata Ganguly, Tanuka Mandal

Keywords : Biomarker, COVID-19, Cytokines

Citation Information : Ganguly S, Mandal T. Cytokine Storm. Bengal Physician Journal 2020; 7 (3):70-71.

DOI: 10.5005/jp-journals-10070-7037

License: CC BY-NC 4.0

Published Online: 01-12-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Cytokine storm is said to occur when increased levels of cytokines are disproportionately produced, with systemic effect and collateral damage to vital organs. It can be caused by both intrinsic (autoimmune) or extrinsic (COVID-19) diseases. In the absence of pathogens, cytokine storm can occur due to immune hyperactivation as a result of inappropriate triggering. Interleukin-6, tumor necrosis factor α, and interleukin-18 are cytokines of clinical importance in cytokine storm. Interleukin-18, a biomarker of severity, correlates with hyperferritinemia and disease flare. The underlying condition should be detected and treatment should be individualized.


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