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VOLUME 8 , ISSUE 2 ( May-August, 2021 ) > List of Articles


ACE Inhibitor-induced Dry Cough and Dysgeusia: COVID-19 Symptom Mimickers—A Case Series

Shambo S Samajdar, Dipan Saha, Satyabrata Sahoo, Sumalya Sen, Santanu K Tripathi

Keywords : Angiotensin-converting enzyme 2, Angiotensin receptor blockers, COVID

Citation Information : Samajdar SS, Saha D, Sahoo S, Sen S, Tripathi SK. ACE Inhibitor-induced Dry Cough and Dysgeusia: COVID-19 Symptom Mimickers—A Case Series. Bengal Physician Journal 2021; 8 (2):49-51.

DOI: 10.5005/jp-journals-10070-7042

License: CC BY-NC 4.0

Published Online: 19-09-2021

Copyright Statement:  Copyright © 2021; The Author(s).


An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in China in the year 2019 has become a global pandemic. SARS-CoV-2 enters the host cell through the angiotensin-converting enzyme 2 (ACE2) receptor, which is known to be down-regulated in COVID-19 infected individuals. ACE inhibitors (ACEI) and angiotensin receptor blockers (ARB) can modulate and most probably up-regulate ACE2 expression and can be a therapeutic option, especially in COVID-19 patients with hypertension. ACEI itself can cause dry cough and loss of taste in some susceptible individuals, which can intimate the symptoms of COVID-19 infection itself and can put the treating physician into a diagnostic dilemma. Careful evaluation and discontinuation of the drug can reverse the symptoms dramatically.

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