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VOLUME 9 , ISSUE 2 ( May-August, 2022 ) > List of Articles


A Challenging Case of Addison's Disease

S Arulrhaj, Arulprakash, Aarathykannan, Chandrakumar, Manikandan, Md Faizur Rahman

Keywords : Addison's disease, Autoimmune, Hyperpigmentation

Citation Information : Arulrhaj S, Arulprakash, Aarathykannan, Chandrakumar, Manikandan, Rahman MF. A Challenging Case of Addison's Disease. Bengal Physician Journal 2022; 9 (2):48-50.

DOI: 10.5005/jp-journals-10070-7089

License: CC BY-NC 4.0

Published Online: 31-08-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Addison's disease (AD) or primary adrenocortical insufficiency results from hypofunction/dysfunction of an adrenal cortex with a decreased production of mineralocorticoids, glucocorticoids, and androgens, and with increased levels of adrenocorticotropic hormone and plasma renin activity. The AD prevalence is 110–144 cases for every million population among the developed countries.1 Autoimmune AD is the most common etiological type in adult patients, which includes about 80% of cases, followed by the second one which is post-tuberculosis AD, seen in 10–15% of the cases, the rest 5% of the cases are caused by neoplastic, vascular, or any rare genetic conditions. The most common form of AD in children is congenital adrenal hyperplasia, and it includes 72% of cases, on the other hand, autoimmune AD is responsible for 10–15% of cases.

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  1. Olafsson AS, Sigurjonsdottir HA. Increasing prevalence of Addison disease: Results from a nationwide study. Endocr Pract 2016;22(1):30–35. DOI: 10.4158/EP15754.OR.
  2. Debono M, Ross RJ. Doses and steroids to be used in primary and central hypoadrenalism. Ann Endocrinol (Paris) 2007;68(4):265–267. DOI: 10.1016/j.ando.2007.06.024.
  3. Kyriazopoulou V. Glucocorticoid replacement therapy in patients with Addison's disease. Expert Opin Pharmacother 2007;8(6):725–729. DOI: 10.1517/14656566.8.6.725.
  4. White K, Arlt W. Adrenal crisis in treated Addison's disease: A predictable but under-managed event. Eur J Endocrinol 2010;162(1):115–120. DOI: 10.1530/EJE-09-0559.
  5. Stewart PM, Krone NP The adrenal cortex. In: Kronenburg HM, Melmed S, Polonsky KS, et al. editors. Williams Textbook of Endocrinology. Chapter 15, 12th ed. Philadelphia PA: Saunders Elsevier; 2011. pp. 515–520.
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