Cardiac resynchronization therapy, Cardiomyopathy, Conduction abnormality, Dyssynchrony, Heart failure with reduced ejection fraction, Left ventricular noncompaction
Citation Information :
Mukhopadhyay M, Som P, Mondal R, Maiti P, Chatterjee N. Left Ventricular Noncompaction Cardiomyopathy Managed with Cardiac Resynchronization Therapy: A Case Report. Bengal Physician Journal 2022; 9 (2):35-40.
Although “spongy myocardium” was first observed by Grant in 1926, left ventricular noncompaction (LVNC) cardiomyopathy was originally described by Engberding and Bender in 1984.1 Left ventricular noncompaction cardiomyopathy is characterized by abnormal ventricular myocardial protrusions with a thin layer of properly compacted myocardium.2,3 It is a rare entity, with a prevalence less than 0.02%.4 We report a case of LVNC cardiomyopathy with dyssynchrony, which was successfully managed with cardiac resynchronization therapy (CRT).
Engberding R, Bender F. Identification of rare congenital anomaly of the myocardium by two-dimensional echocardiography. Persistence of isolated myocardial sinusoids. Am J Cardiol 1984;53(11):1733–1734. DOI: 10.1016/0002-9149(84)90618-0.
Samsa LA, Yang B, Liu J. Embryonic cardiac chamber maturation: trabeculation, conduction and cardiomyocyte proliferation. Am J Med Genet Part C Semin Med Genet 2013;163C(3):157–168. DOI: 10.1002/ajmg.c.31366.
Towbin JA, Lorts A, Jefferies JL. Left ventricular non-compaction cardiomyopathy. Lancet 2015;386(9995):813–825. DOI: 10.1016/S0140-6736(14)61282-4.
Tamborini G, Pepi M, Celeste F, et al. Incidence and characteristics of left ventricular false tendons and trabeculations in the normal and pathologic heart by second harmonic echocardiography. J Am Soc Echocardiogr 2004;17(4):367–374. DOI: 10.1016/j.echo.2003.12.020.
Kayvanpour E, Sedaghat-Hamedani F, Gi WT, et al. Clinical and genetic insights into non-compaction: a meta-analysis and systematic review on 7598 individuals. Clin Res Cardiol 2019;108(11):1297–1308. DOI: 10.1007/s00392-019-01465-3.
Udeoji DU, Philip KJ, Morrissey RP, et al. Left ventricular noncompaction cardiomyopathy: updated review. Ther Adv Cardiovasc Dis 2013;7(5):260–273. DOI: 10.1177/1753944713504639.
Miyake CY, Kim JJ. Arrhythmias in left ventricular noncompaction. Card Electrophysiol Clin 2015;7(2):319–330. DOI: 10.1016/j.ccep.2015.03.007.
Mavrogeni SI, Bacopoulou F, Apostolaki D, et al. Sudden cardiac death in athletes and the value of cardiovascular magnetic resonance. Eur J Clin Invest 2018;48(7):e12955. DOI: 10.1111/eci.12955.
Kido K, Guglin M. Anticoagulation therapy in specific cardiomyopathies: isolated left ventricular noncompaction and peripartum cardiomyopathy. J Cardiovasc Pharmacol Ther 2019;24(1):31–36. DOI: 10.1177/1074248418783745.
Jenni R, Oechslin E, Schneider J, et al. Echocardiographic and pathoanatomical characteristics of isolated left ventricular non-compaction: a step towards classification as a distinct cardiomyopathy. Heart 2001;86(6):666–671. DOI: 10.1136/heart.86.6.666.
Peterson SE, Selvanayagam JB, Wiesmann F, et al. Left ventricular non-compaction: insights from cardiovascular magnetic resonance imaging. J Am Coll Cardiol 2005;46(1):101–105. DOI: 10.1016/j.jacc.2005.03.045.