Bengal Physician Journal

Register      Login

VOLUME 9 , ISSUE 3 ( September-December, 2022 ) > List of Articles

CASE REPORT

Autoimmunity and Immunodeficiency Coexisting in the Same Patient

Mugundhan Krishnan, Kamatchi Sundaramoorthy, Muralidharan Kamalakannan, Sakthi Velayudham, Viveka Saravanan Raju

Keywords : Acetylcholine receptor antibodies, Esophageal candidiasis, Good syndrome, Mucocutaneous candidiasis, Myasthenia gravis, Thymoma, Weight loss

Citation Information : Krishnan M, Sundaramoorthy K, Kamalakannan M, Velayudham S, Raju VS. Autoimmunity and Immunodeficiency Coexisting in the Same Patient. Bengal Physician Journal 2022; 9 (3):73-74.

DOI: 10.5005/jp-journals-10070-7083

License: CC BY-NC 4.0

Published Online: 06-01-2023

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Myasthenia gravis is a well-known autoimmune disorder. Very few cases in literature showed association of myasthenia gravis, thymoma, and oral candidiasis. Here, we present a case of myasthenia gravis with thymoma, significant weight loss, extensive oral and esophageal candidiasis mimicking an immunodeficiency state which often creates a therapeutic dilemma in instituting immunosuppression.


HTML PDF Share
  1. Boras VV, Bralio V, Sostarko M. Candidiasis associated with thymoma and myasthenia gravis. Oral Oncol Extra 2005;41:56–59. DOI: 10.1016/j.ooe.2004.11.002.
  2. Jansen A, van Deuren N, Miller J, et al. Prognosis of good syndrome: mortality and morbidity of thymoma associated immunodeficiency in perspective. Clin Immunol 2016;171:12–17. DOI: 10.1016/j.clim.2016.07.025.
  3. Paranavitane S, Handagala S, De Silva R, et al. Thymoma complicated with myasthenia gravis and Good syndrome–a therapeutic conundrum: a case report. J Med Case Rep 2019;13(1):348. DOI: 10.1186/s13256-019-2289-z.
  4. Grammatikos A, Donati M, Johnston SL, et al. Cell deficiency and predisposition to viral infections: the paradigm of immune deficiencies. Front Immunol 2021;12:731643. DOI: 10.3389/fimmu.2021.731643.
  5. Weksler B, Lu B. Alteration of the immune system in the thymic malignancies. J Thorac Oncol 2014;9(Suppl. 2):S137–S142. DOI: 10.1097/JTO, 0000000000000299.
  6. Porter SR, Scully C. Orofacial manifestations in primary immunodeficiencies: T lymphocyte defects. J Oral Pathol Med 1993;22: 308–309. https://doi.org/10.1111/j.1600-0714.1993.tb01078.x.
  7. Rothberg MS, Eisenbud L, GRiboff S. Chronic mucocutaneous candidiasis–thymoma syndrome. Oral Surf Oral Med Oral Pathol 1989;68:411–413. https://doi.org/10.1016/0030-4220(89)90138-2.
  8. Lefebvre JL, Domenge C. A comparative study of efficacy and safety of fluconazole oral suspension and amphotericin B oral suspension in cancer patients with mucositis. Oral Oncol 2002;38:337–342. https://doi.org/10.1016/s1368-8375(01)00063-x.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.