Tacrolimus-associated Pruritus: A Case Report and Review

Shambo S Samajdar

doi:10.5005/jp-journals-10070-7018

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Tacrolimus-associated Pruritus: A Case Report and Review

Shambo S Samajdar

Keywords : Everolimus, Pruritus, Solid organ transplantation, Tacrolimus

Citation Information : Samajdar SS. Tacrolimus-associated Pruritus: A Case Report and Review. Bengal Physician Journal 2020; 7 (1):12-13.

DOI: 10.5005/jp-journals-10070-7018

License: CC BY-NC 4.0

Published Online: 18-02-2021

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Abstract

The use of immunosuppressants following solid organ transplantation has become a general procedure nowadays. Various immunosuppressants have been used—among them tacrolimus, is a calcineurin inhibitor (CNI) and macrolide antibiotic has been chosen widely. But significant complaints associated with tacrolimus have been reported, for example, severe pruritus. As a result, physicians are required to substitute this one without compromising the intended therapeutic effect, minimizing adverse drug reactions. Everolimus becomes the best alternative, which is also a mammalian target of rapamycin (mTOR) inhibitor with a comparatively wide therapeutic index as compared to tacrolimus. This present reporting is about the tacrolimus-associated pruritus which was severe and how the patient compliance has been ensured keeping in mind the other comorbidities.

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