This is a case report of an immunocompromised adult female presented with fever and reddish-colored spots all over the body along with bilateral swelling of parotid and submandibular glands. Hematological parameters revealed pancytopenia, and she was diagnosed with disseminated histoplasmosis by bone marrow trephine biopsy. The patient was treated with antimicrobials and other supportive therapy, but she rapidly deteriorated and succumbed to the underlying bone marrow infiltration and failure.
Evrard S, Caprasse P, Gavage P, et al. Disseminated histoplasmosis: Case report and review of the literature. Acta Clin Belg 2018;73(5):356–363. DOI: 10.1080/17843286.2017.1376454.
Samaddar A, Sharma A, Ph AK, et al. Disseminated histoplasmosis in immunocompetent patients from an arid zone in Western India: A case series. Med Mycol Case Rep 2019;25:49–52. DOI: 10.1016/j.mmcr.2019.07.012.
Jameson JL, Fauci AS, Kasper DL, et al. Harrison's Principles of Internal Medicine. 20th edition, McGraw-Hill Education, 2018.
Lugo A, Adjapong A, Ahmad W. Histoplasmosis: Fever of unknown origin disseminated to bone marrow.