Background: Treatment choice and therapeutic targets in diabetes care are much individualized and are based on not only clinical data but also patient parameters. A multidisciplinary collaboration in care delivery can help achieving the glycemic targets and improving patients’ quality of life simultaneously. This study aimed to evaluate the effect of clinical pharmacological (CP) consultation in optimizing diabetes care. Methods: A cross-sectional observational study included patients from both groups—those receiving CP consultation as an add-on and those not. Each patient was interviewed for awareness on hypoglycemic alert, insulin injection technique, importance of self-monitoring of blood glucose (SMBG) and foot care, dietary advices, exercise prescription, and sensitization regarding adverse drug reactions (ADRs). Treatment adherence and potential drug–drug interactions (DDI) were also noted for each group and results were statistically analyzed. Results: Significantly higher awareness regarding hypoglycemic alert, insulin injection technique, importance of SMBG, and ADR sensitization was noted in those receiving CP consultation (p < 0.05). Adherence was also significantly higher in such patients and (DDI) significantly lower (p < 0.001). Conclusion: Better patient knowledge can have significant influence on self-care behavioral practices. As diabetes care goes a long way and treatment approaches should be primarily patient-centric, a co-professional support can further aid in optimizing better and safer patient outcomes.