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VOLUME 10 , ISSUE 2 ( May-August, 2023 ) > List of Articles


Incretin-based Antidiabetic Therapy and Pancreatitis: A Case Series

Arijit Kayal, Dipan Saha, Anindya Karmakar, Debarati Bhar, Pranesh Sarkar

Keywords : Acute pancreatitis, Case report, Diabetes mellitus, GLP-1 agonist

Citation Information : Kayal A, Saha D, Karmakar A, Bhar D, Sarkar P. Incretin-based Antidiabetic Therapy and Pancreatitis: A Case Series. Bengal Physician Journal 2023; 10 (2):69-70.

DOI: 10.5005/jp-journals-10070-8012

License: CC BY-NC 4.0

Published Online: 07-08-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Dipeptidyl peptidase-4 (DPP-4) inhibitors, commonly referred to as gliptins, are a class of oral antihyperglycemic agents used for the management of type 2 diabetes mellitus. They work by inhibiting the enzyme DPP-4, which leads to increased levels of incretin hormones such as glucagon-like peptide-1 (GLP-1). On the contrary, glucagon-like peptide 1 receptor agonists (GLP-1RA) are the newest treatment for diabetes mellitus (DM). Many of these incretin-based agents have shown positive results in their respective cardiovascular outcome trials (CVOT). Acute pancreatitis is a condition that has been a subject of concern in relation to incretin-based therapies, as reported in some randomized clinical trials. Here, we present three such cases of pancreatitis related to this antidiabetic therapy.

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  2. Elashoff M, Matveyenko AV, Gier B, et al. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology 2011;141(1):150–156. DOI: 10.1053/j.gastro.2011. 02.018.
  3. Roshanov PS, Dennis BB. Incretin-based therapies are associated with acute pancreatitis: Meta-analysis of large randomized controlled trials. Diabetes Res Clin Pract 2015;110(3):e13–17. DOI: 10.1016/j.diabres. 2015.10.014.
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