Bengal Physician Journal

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Volume  11 (2024)
Volume  10 (2023)
Volume  9 (2022)
Volume  8 (2021)
Volume  7 (2020)
Volume  6 (2019)
Volume  5 (2018)
Related articles

VOLUME 11 , ISSUE 2 ( May-August, 2024 ) > List of Articles

COMMENTARY

Monotherapy is Recommended in the Treatment of Scrub Typhus and Doxycycline Resistance is a Misconception

Abheek Sil, Atanu Chandra, Uddalak Chakraborty

Keywords : Azithromycin, Doxycycline, Orientia tsutsugamushi, Scrub typhus

Citation Information : Sil A, Chandra A, Chakraborty U. Monotherapy is Recommended in the Treatment of Scrub Typhus and Doxycycline Resistance is a Misconception. Bengal Physician Journal 2024; 11 (2):89-91.

DOI: 10.5005/jp-journals-10070-8047

License: CC BY-NC 4.0

Published Online: 06-07-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract
PDF Share
  1. Chakraborty S, Sarma N. Scrub typhus: An emerging threat. Indian J Dermatol 2017;62(5):478–485. DOI: 10.4103/ijd.IJD_388_17.
  2. Seong SY, Choi MS, Kim IS. Orientia tsutsugamushi infection: Overview and immune responses. Microbes Infect 2001;3(1):11–21. DOI: 10.1016/s1286-4579(00)01352-6.
  3. Wee I, Lo A, Rodrigo C. Drug treatment of scrub typhus: A systematic review and meta-analysis of controlled clinical trials. Trans R Soc Trop Med Hyg 2017;111(8):336–344. DOI: 10.1093/trstmh/trx066.
  4. Navarro-Triviño FJ, Pérez-López I, Ruiz-Villaverde R. Doxycycline, an antibiotic or an anti-inflammatory agent? The most common uses in dermatology. Actas Dermosifiliogr (Engl Ed) 2020;111(7):561–566. DOI: 10.1016/j.ad.2019.12.006.
  5. Watt G, Chouriyagune C, Ruangweerayud R, et al. Scrub typhus infections poorly responsive to antibiotics in northern Thailand. Lancet 1996;348(9020):86–89. DOI: 10.1016/s0140-6736(96) 02501-9.
  6. Strickman D, Sheer T, Salata K, et al. In vitro effectiveness of azithromycin against doxycycline-resistant and -susceptible strains of Rickettsia tsutsugamushi, etiologic agent of scrub typhus. Antimicrob Agents Chemother 1995;39(11):2406–2410.
  7. Thipmontree W, Tantibhedhyangkul W, Silpasakorn S, et al. Scrub Typhus in Northeastern Thailand: Eschar Distribution, abnormal electrocardiographic findings, and predictors of fatal outcome. Am J Trop Med Hyg 2016;95(4):769–773. DOI: 10.4269/ajtmh.16-0088.
  8. Lee SH, Chung EJ, Kim EG, et al. A case of doxycycline-resistant tsutsugamushi meningoencephalitis. Neurology Asia 2014;19: 205–206.
  9. Mathai E, Rolain JM, Verghese GM, et al. Outbreak of scrub typhus in southern India during the cooler months. Ann N Y Acad Sci 2003;990:359–364. DOI: 10.1111/j.1749-6632.2003.tb07391.x.
  10. Harris PNA, Oltvolgyi C, Islam A, et al. An outbreak of scrub typhus in military personnel despite protocols for antibiotic prophylaxis: Doxycycline resistance excluded by a quantitative PCR-based susceptibility assay. Microbes Infect 2016;18(6):406–411. DOI: 10.1016/j.micinf.2016.03.006.
  11. Corwin A, Soderquist R, Suwanabun N, et al. Scrub typhus and military operations in Indochina. Clin Infect Dis 1999;29(4):940–941. DOI: 10.1086/520468.
  12. Rosenberg R. Drug-resistant scrub typhus: Paradigm and paradox. Parasitol Today 1997;13(4):131–132. DOI: 10.1016/s0169-4758(97)01020-x.
  13. Sonthayanon P, Peacock SJ, Chierakul W, et al. High rates of homologous recombination in the mite endosymbiont and opportunistic human pathogen Orientia tsutsugamushi. PLoS Negl Trop Dis 2010;4(7):e752. DOI: 10.1371/journal.pntd.0000752.
  14. Kelly DJ, Fuerst PA, Richards AL. The historical case for and the future study of antibiotic-resistant scrub typhus. Trop Med Infect Dis 2017;2(4):63. DOI: 10.3390/tropicalmed2040063.
  15. Phuklia W, Panyanivong P, Sengdetka D, et al. Novel high-throughput screening method using quantitative PCR to determine the antimicrobial susceptibility of Orientia tsutsugamushi clinical isolates. J Antimicrob Chemother 2019;74(1):74–81. DOI: 10.1093/jac/dky402.
  16. Wangrangsimakul T, Phuklia W, Newton PN, et al. Scrub typhus and the misconception of doxycycline resistance. Clin Infect Dis 2020;70(11):2444–2449. DOI: 10.1093/cid/ciz972.
  17. Watt G, Kantipong P, Jongsakul K. Doxycycline and rifampicin for mild scrub-typhus infections in northern Thailand: A randomised trial. Lancet 2000;356(9235):1057–1061. DOI: 10.1016/S0140-6736(00) 02728-8.
  18. Barnabas R, Abhilash K, Varghese GM, et al. Prospective study to assess the treatment modalities and fever defervescence in patients with scrub typhus from a tertiary care centre in South India. J Vector Borne Dis 2021;58(1):33–38. DOI: 10.4103/0972-9062.321748.
  19. Arun Babu T, Narayanasamy DK, Mathiyalagen P. Comparative efficacy of doxycycline vs. azithromycin in pediatric scrub typhus. Indian J Pediatr 2021;88(1):93. DOI: 10.1007/s12098-020-03469-8.
  20. Pachiappan N, Gane BD. Comparison of doxycycline and azithromycin for the treatment of scrub typhus in children. J Evolution Med Dent Sci 2016;5(20):998–1000, DOI: 10.14260/jemds/2016/232.
  21. Lee M, Kim J, Jo DS. Effects of clarithromycin treatment in scrub typhus in children: Comparison with chloramphenicol and azithromycin. Korean J Pediatr 2017;60(4):124–127. DOI: 10.3345/kjp.2017.60.4.124.
  22. Zhao M, Wang T, Yuan X, et al. Comparison of minocycline and azithromycin for the treatment of mild scrub typhus in northern China. Int J Antimicrob Agents 2016;48(3):317–320. DOI: 10.1016/j.ijantimicag.2016.05.019.
  23. Varghese GM, Dayanand D, Gunasekaran K, et al. INTREST Trial investigators. Intravenous doxycycline, azithromycin, or both for severe scrub typhus. N Engl J Med 2023;388(9):792–803. DOI: 10.1056/NEJMoa2208449.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.