Indigenous Herbal Drug (Tinospora Cordifolia) Induced Liver Injury: A Case Report

Sounak Kumar Roy; Muniruddin SK; Subham Mondal; Sandipan Mukherjee; Santa Subhra Chatterjee

doi:10.5005/jp-journals-10070-8064

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Indigenous Herbal Drug (Tinospora Cordifolia) Induced Liver Injury: A Case Report

Sounak Kumar Roy, Muniruddin SK, Subham Mondal, Sandipan Mukherjee, Santa Subhra Chatterjee

Keywords : Case report, Drug induced liver injury, Giloy, Herbal induced liver injury, Tinospora cordifolia

Citation Information : Roy SK, SK M, Mondal S, Mukherjee S, Chatterjee SS. Indigenous Herbal Drug (Tinospora Cordifolia) Induced Liver Injury: A Case Report. Bengal Physician Journal 2025; 12 (1):43-45.

DOI: 10.5005/jp-journals-10070-8064

License: CC BY-NC 4.0

Published Online: 20-03-2025

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Abstract

Drug-induced liver injury (DILI) is a condition characterized by acute or chronic liver damage following the use of hepatotoxic drugs. It can be classified based on clinical presentation (hepatocellular, cholestasis, or mixed), mechanism of hepatotoxicity, or histological appearance. Drug-induced liver injury also includes cases related to herbal-induced liver injury (HILI). Diagnosing DILI requires excluding other potential causes and identifying a consistent pattern of liver involvement. The pathogenesis typically involves the parent drug or its metabolites, which may directly impact cell biochemistry or trigger an immune response. The specific drug involved influences the pattern of liver function abnormalities, the latency period before symptom onset, the presence of immune-mediated hypersensitivity, and the response to drug discontinuation. The case discussed illustrates a DILI caused by an indigenous herbal drug, highlighting the complexities of identifying and managing liver injury in such scenarios.

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